First-in-class novel molecules
The lead asset class of glycomacrolides are potent and selective inhibitors of the F1 subunit of ATP synthase/hydrolase with optimal pharmacology, and a wide therapeutic index in patient-derived tumor models. EB6103 and EB9092 are novel bioengineered compounds undergoing IND enabling studies. Undisclosed leads in discovery and optimization continue to make their way toward the clinic.